Analytical Data
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基因名
AK1
- Application
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别名
AK1；Aldo-keto reductase family 1 member B15
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P00568
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表达区间
1-194aa
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氨基酸序列
MEEKLKKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVAKVNTSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHLDALK
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分子量
37.6kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AK1 (Adenylate Kinase 1) is an essential enzyme involved in cellular energy homeostasis, playing a critical role in the transfer of phosphate groups in the ATP-ADP cycle. The significance of AK1 has been underscored in various research studies focusing on its involvement in energy metabolism, cellular stress responses, and apoptosis. Dysregulation of AK1 has been associated with several pathological conditions, including cancer and neurodegenerative diseases, where altered energy balance contributes to disease progression. Moreover, AK1 is also significant in certain parasitic organisms, making it a potential target for therapeutic interventions. Recent advancements in recombinant protein technology have enabled the production of AK1 in heterologous systems, allowing for detailed characterization of its enzymatic activity, structural properties, and interaction with other cellular components. Understanding the structure-function relationship of AK1 at the molecular level provides insights into its mechanisms of action and opens avenues for the development of AK1-targeted drugs or therapeutic strategies. As research continues to unveil the multifaceted roles of AK1, it holds promise as a crucial player in both basic biology and therapeutic development.
