Analytical Data
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Gene name
AR
- Application
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Alternative Names
AR；AFAR2；Aflatoxin B1 aldehyde reductase member 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95154
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Expression Region
1-331aa
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AA Sequence
MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVAHECPNYFR
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Molecular Weight
64.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The research on androgen receptor (AR) translocation and protein restructuring has gained significant attention due to its pivotal role in prostate cancer progression. The androgen receptor is a nuclear hormone receptor that regulates gene expression in response to androgens, such as testosterone. In the context of prostate cancer, AR undergoes various mutations and modifications that can lead to its aberrant activation, even in the presence of anti-androgens. This misregulation often results in increased cellular proliferation and survival, contributing to the malignancy's aggressiveness. Researchers are increasingly focusing on understanding the mechanisms behind AR's structural changes and its interactions with co-regulators, which can provide insights into developing targeted therapies. Furthermore, studying AR's role in the context of various signaling pathways may illuminate novel avenues for intervention. As resistance to conventional treatments remains a critical challenge in prostate cancer management, unraveling the complexities of AR reorganization and function has the potential to inform therapeutic strategies and improve clinical outcomes. The integration of advanced techniques such as cryo-electron microscopy and proteomics continues to enhance our understanding of AR dynamics, underscoring the need for continued research in this area.
