Analytical Data
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基因名
ADRM1
- Application
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别名
ADRM1；GP110；Proteasomal ubiquitin receptor ADRM1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16186
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表达区间
1-407aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSHMTTSGALFPSLVPGSRGASNKYLVEF RAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIF PDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNE YLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAG LGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTR ATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNV PAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADE IQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEA FAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD
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分子量
45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADRM1, also known as Acidic Dipeptidase and Regulator of Mitochondrial Apoptosis 1, is a protein implicated in various cellular processes, including apoptosis, mitochondrial function, and stress responses. The role of ADRM1 in regulating the cellular stress response makes it a significant focus of research, particularly in the context of cancer and neurodegenerative diseases where mitochondrial dysfunction is a hallmark. Studies have shown that ADRM1 contributes to the regulation of proteasomal activity and protein homeostasis, which are crucial for maintaining cellular health. Additionally, its involvement in apoptosis signaling pathways suggests that ADRM1 may serve as a potential therapeutic target. Advances in recombinant protein technology allow for the production and purification of ADRM1, facilitating detailed studies into its structure, function, and interactions within cells. Understanding the functional implications of ADRM1 and its role in disease mechanisms could lead to novel therapeutic strategies aimed at modulating its activity to promote cell survival or induce apoptosis in cancer cells. As a result, the research around ADRM1 recombinant proteins has gained momentum, offering promising insights that bridge the gap between fundamental biology and potential clinical applications.
