Analytical Data
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Gene name
UGT1A7
- Application
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Alternative Names
(UGT1A7)(UDP-glucuronosyltransferase 1-7)(UDPGT 1-7)(UGT1*7)(UGT1-07)(UGT1.7)(UDP-glucuronosyltransferase 1-G)(UGT-1G)(UGT1G)
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HAW7
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Expression Region
26-530aa
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Molecular Weight
60.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UGT1A7 is a member of the uridine diphosphate-glucuronosyltransferase (UGT) family, which plays a crucial role in the metabolism of various endogenous and exogenous compounds through glucuronidation. This biochemical process enhances the solubility of lipophilic substances, facilitating their excretion from the body. The UGT1A7 gene is particularly significant due to its involvement in the glucuronidation of phenolic compounds, certain drugs, and environmental toxins, which can influence drug metabolism, toxicity, and pharmacokinetics. Variations in the UGT1A7 gene have been linked to differences in drug responses and disease susceptibility among individuals. Given its relevance in pharmacogenomics and toxicology, research on UGT1A7 recombinant protein aims to elucidate its enzymatic properties, substrate specificity, and regulation. Understanding the functional dynamics of UGT1A7 can provide insights into individual variations in drug metabolism and pave the way for personalized medicine approaches. Additionally, the recombinant protein can be used for high-throughput screening in drug discovery and to assess the impact of genetic polymorphisms on UGT1A7 activity. Overall, the study of UGT1A7 and its recombinant protein is vital for advancing our knowledge in pharmacology, toxicology, and the development of therapeutic strategies.
