Cat: PA1000-8909

Recombinant Human IGFALS Protein,His

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Analytical Data

  • Gene name

    IGFALS

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    IGFALS;ALS;Insulin-like growth factor-binding Protein complex acid labile subunit

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    P35858

  • Expression Region

    1-605aa

  • AA Sequence

    MALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYD DDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALAS LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELV LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLD RNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL QEVKAGAFLGLTNMAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLP HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNS LLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDF ALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEA HFAPC

  • Molecular Weight

    93 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

IGFALS (Insulin-like Growth Factor Acid-Labile Subunit) is a crucial component of the insulin-like growth factor (IGF) axis, which plays a significant role in growth and development, as well as in metabolic processes. It primarily functions by forming stable complexes with IGF1 and IGF2, extending their half-lives and modulating their bioavailability. Research on IGFALS is driven by its implications in various physiological conditions and diseases, including growth disorders, obesity, and certain cancers. Genetic mutations in the IGFALS gene can lead to abnormal levels of IGF, affecting growth patterns and metabolic functions, emphasizing the need for understanding its structure and function in depth. Given the complexity of the IGF system and its diverse biological effects, the recombinant production of IGFALS protein has garnered attention. Studies focusing on the expression and characterization of recombinant IGFALS can provide insights into its role in the IGF signaling pathway and its potential therapeutic applications. By elucidating the biological mechanisms and interactions involving IGFALS, researchers hope to uncover novel strategies for treating IGF-related disorders and improving overall health outcomes.

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