Analytical Data
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基因名
IGFALS
- Application
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别名
IGFALS；ALS；Insulin-like growth factor-binding Protein complex acid labile subunit
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35858
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表达区间
1-605aa
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氨基酸序列
MALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYD DDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALAS LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELV LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLD RNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL QEVKAGAFLGLTNMAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLP HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNS LLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDF ALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEA HFAPC
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分子量
93 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IGFALS (Insulin-like Growth Factor Acid-Labile Subunit) is a crucial component of the insulin-like growth factor (IGF) axis, which plays a significant role in growth and development, as well as in metabolic processes. It primarily functions by forming stable complexes with IGF1 and IGF2, extending their half-lives and modulating their bioavailability. Research on IGFALS is driven by its implications in various physiological conditions and diseases, including growth disorders, obesity, and certain cancers. Genetic mutations in the IGFALS gene can lead to abnormal levels of IGF, affecting growth patterns and metabolic functions, emphasizing the need for understanding its structure and function in depth. Given the complexity of the IGF system and its diverse biological effects, the recombinant production of IGFALS protein has garnered attention. Studies focusing on the expression and characterization of recombinant IGFALS can provide insights into its role in the IGF signaling pathway and its potential therapeutic applications. By elucidating the biological mechanisms and interactions involving IGFALS, researchers hope to uncover novel strategies for treating IGF-related disorders and improving overall health outcomes.
