Analytical Data
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基因名
IRS3
- Application
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别名
IRS3；
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14653
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表达区间
2-427aa
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氨基酸序列
MASMTGGQQMGRGHHHHHHENLYFQGEFGTPKPRILPWLVSQLDLGQLEG VAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGRDKPDL PTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQPDTS PDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRS PSLDNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCP EGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLA LWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLG PFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLR ALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQG PGES
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分子量
50 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IRS3 (insulin receptor substrate 3) is a key adapter protein involved in insulin signaling and metabolic regulation. Its role in mediating the effects of insulin on glucose uptake, lipid metabolism, and cell growth has garnered significant interest in the field of diabetes and obesity research. IRS3 exists as a member of the IRS family, which also includes IRS1 and IRS2, and its expression and functional dynamics are closely linked to various metabolic disorders. Recent studies have indicated that IRS3 may influence insulin sensitivity and resistance, making it a potential target for therapeutic interventions aimed at treating type 2 diabetes and related conditions. Furthermore, the characterization of IRS3 as a recombinant protein has facilitated investigations into its structure-function relationships, signaling pathways, and interactions with other molecules involved in metabolic networks. Understanding IRS3's mechanisms may provide insights for developing novel strategies to enhance insulin action and improve metabolic homeostasis, paving the way for innovative treatments directly targeting the underlying causes of insulin resistance. As a result, IRS3 recombinant protein research is critical for elucidating the complexities of insulin signaling and metabolic health, contributing to both basic science and clinical applications in endocrinology and metabolic disease management.
