Analytical Data
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基因名
ATXN2
- Application
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别名
(Spinocerebellar ataxia type 2 protein)(Trinucleotide repeat-containing gene 13 protein)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99700
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表达区间
481-775aa
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分子量
37.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATXN2, or Ataxin-2, is a protein encoded by the ATXN2 gene, which is primarily associated with neurodegenerative diseases, particularly spinocerebellar ataxia type 2 (SCA2). Research into ATXN2 has gained significant attention due to its role in RNA metabolism, stress granule formation, and the pathogenesis of several neurodegenerative disorders. The protein is known to interact with various RNA-binding proteins and play a crucial role in cellular responses to stress, making it an important factor in the maintenance of neuronal health. Mutations or expansions in the polyglutamine (polyQ) region of ATXN2 are linked to SCA2, underscoring its relevance in the study of hereditary ataxias. Additionally, studies have suggested that ATXN2 may influence the progression of other neurodegenerative diseases such as ALS (amyotrophic lateral sclerosis) and Alzheimer's disease. The generation and study of recombinant ATXN2 proteins allow researchers to investigate the structural and functional properties of this protein, explore its interactions with other cellular components, and assess the impact of specific mutations. Understanding the biology of ATXN2 through recombinant protein studies is crucial for elucidating its role in disease mechanisms and may contribute to the development of targeted therapeutic strategies for conditions associated with ATXN2 dysfunction.
