Analytical Data
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基因名
IRS1
- Application
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别名
IRS1；Insulin receptor substrate 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35568
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表达区间
157-267aa
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氨基酸序列
GPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPR
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分子量
60.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IRS1 (Insulin Receptor Substrate 1) is a crucial adaptor protein involved in insulin signaling and metabolic regulation. It plays a vital role in mediating the effects of insulin and other growth factors by facilitating communication between the insulin receptor and downstream signaling pathways, including the PI3K-AKT and MAPK pathways. Recent research has indicated that IRS1 is not only important for glucose homeostasis but also influences lipid metabolism and cellular growth. Dysregulation or mutations in IRS1 are associated with various metabolic disorders, including obesity, type 2 diabetes, and insulin resistance. As such, IRS1 has garnered significant interest in the fields of endocrinology and metabolic research. Researchers are investigating IRS1's structure-function relationships, its post-translational modifications, and its interactions with other signaling proteins to better understand how it regulates metabolic processes. The study of recombinant IRS1 proteins is pivotal in these investigations, as it allows for detailed analyses of its biochemical properties and the effects of specific mutations. Overall, the exploration of IRS1, particularly through recombinant protein studies, holds promise for developing therapeutic strategies aimed at improving metabolic health and addressing associated diseases.
