Analytical Data
-
Gene name
US11
- Application
-
Alternative Names
Vmw21
-
Species
Human herpesvirus
-
Source
E. coli
-
Tag
N- His & C- Myc
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P04487
-
Expression Region
1-161aa
-
Molecular Weight
25.2 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
US11 is a protein encoded by the human cytomegalovirus (HCMV) that plays a crucial role in the virus's ability to evade the host immune response. It is classified as a glycoprotein and is primarily involved in disrupting the normal function of MHC class I molecules, which are essential for presenting viral antigens to CD8+ T cells. By interfering with the expression and transport of these molecules on the surface of infected cells, US11 helps HCMV to escape detection by the immune system, thus enhancing viral persistence and contributing to the pathogenesis of HCMV infections. Research into US11 and its mechanisms is vital not only for understanding HCMV biology but also for developing therapeutic strategies to combat this common yet potentially serious virus, particularly in immunocompromised individuals such as organ transplant recipients. Studies have shown that US11 can interact with various cellular proteins and utilize the endoplasmic reticulum-associated degradation (ERAD) pathway to facilitate its functions. Given its significant role in immune evasion, US11 has emerged as a potential target for antiviral therapies and vaccines. Understanding the structural and functional dynamics of US11 could provide deeper insights into viral pathogenesis and lead to innovative approaches to mitigate HCMV-related diseases. Furthermore, insights gained from US11 research may have broader implications for other viral infections and therapeutic strategies aimed at modulating the immune response.
