Analytical Data
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Gene name
NOSIP
- Application
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Alternative Names
NOSIP；Nitric oxide synthase-interacting Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y314
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Expression Region
1-301aa
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AA Sequence
MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGTRREEQK ELQRAASQDH VRGFLEKESA IVSRPLNPFT AKALSGTSPD DVQPGPSVGP PSKDKDKVLP SFWIPSLTPE AKATKLEKPS RTVTCPMSGK PLRMSDLTPV HFTPLDSSVD RVGLITRSER YVCAVTRDSL SNATPCAVLR PSGAVVTLEC VEKLIRKDMV DPVTGDKLTD RDIIVLQRGG TGFAGSGVKL QAEKSRPVMQ A
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NOSIP (Nitric Oxide Synthase Interacting Protein) is a critical regulator of nitric oxide (NO) synthesis, which plays a vital role in various physiological processes, including vascular regulation, neurotransmission, and immune responses. Research into NOSIP has gained momentum due to its involvement in cardiovascular diseases, neurodegenerative disorders, and inflammatory conditions. Dysfunctional regulation of NO production can lead to pathologies such as hypertension, atherosclerosis, and neuroinflammation, emphasizing the importance of understanding the mechanisms governing NOSIP's interaction with nitric oxide synthases (NOS). The elucidation of NOSIP's role at the molecular level has potential therapeutic implications, as modulation of its activity could offer new avenues for drug development aimed at restoring normal NO levels and mitigating disease progression. Furthermore, the study of NOSIP and its interactions provides insight into the broader signaling pathways influenced by NO, fostering a deeper understanding of its diverse biological functions. As research progresses, the characterization of NOSIP as a therapeutic target continues to attract attention, highlighting its relevance in both basic and translational science.
