Analytical Data
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基因名
NOSIP
- Application
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别名
NOSIP；Nitric oxide synthase-interacting Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y314
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表达区间
1-301aa
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氨基酸序列
MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGTRREEQK ELQRAASQDH VRGFLEKESA IVSRPLNPFT AKALSGTSPD DVQPGPSVGP PSKDKDKVLP SFWIPSLTPE AKATKLEKPS RTVTCPMSGK PLRMSDLTPV HFTPLDSSVD RVGLITRSER YVCAVTRDSL SNATPCAVLR PSGAVVTLEC VEKLIRKDMV DPVTGDKLTD RDIIVLQRGG TGFAGSGVKL QAEKSRPVMQ A
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NOSIP (Nitric Oxide Synthase Interacting Protein) is a critical regulator of nitric oxide (NO) synthesis, which plays a vital role in various physiological processes, including vascular regulation, neurotransmission, and immune responses. Research into NOSIP has gained momentum due to its involvement in cardiovascular diseases, neurodegenerative disorders, and inflammatory conditions. Dysfunctional regulation of NO production can lead to pathologies such as hypertension, atherosclerosis, and neuroinflammation, emphasizing the importance of understanding the mechanisms governing NOSIP's interaction with nitric oxide synthases (NOS). The elucidation of NOSIP's role at the molecular level has potential therapeutic implications, as modulation of its activity could offer new avenues for drug development aimed at restoring normal NO levels and mitigating disease progression. Furthermore, the study of NOSIP and its interactions provides insight into the broader signaling pathways influenced by NO, fostering a deeper understanding of its diverse biological functions. As research progresses, the characterization of NOSIP as a therapeutic target continues to attract attention, highlighting its relevance in both basic and translational science.
