Analytical Data
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Gene name
NOS1AP
- Application
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Alternative Names
NOS1AP；CAPON；KIAA0464；Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75052
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Expression Region
1-506aa
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AA Sequence
MPSKTKYNLVDDGHDLRIPLHNEDAFQHGICFEAKYVGSLDVPRPNSRVE IVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKLLLLQKKEWT WDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKK KSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSNSSGDPGR QLTGAERASTATAEETDIDAVEVPLPGNDVLEFSRGVTDLDAVGKEGGSH TGSKVSHPQEPMLTASPRMLLPSSSSKPPGLGTETPLSTHHQMQLLQQLL QQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHIS LLVKQVQELELKLSGQNAMGSQDSLLEITFRSGALPVLCDPTTPKPEDLH SPPLGAGLADFAHPAGSPLGRRDCLVKLECFRFLPPEDTPPPAQGEALLG GLELIKFRESGIASEYESNTDESEERDSWSQEELPRLLNVLQRQELGDGL DDEIAV
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Molecular Weight
83 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NOS1AP, or neuronal nitric oxide synthase 1 associated protein, plays a critical role in the regulation of neuronal signaling and has been implicated in various neurological disorders. Research indicates that NOS1AP interacts with the nNOS enzyme, influencing nitric oxide production, which is crucial for neurotransmission and synaptic plasticity. The protein is encoded by the NOS1AP gene, located on chromosome 1, and variations in this gene have been associated with several psychiatric conditions, including schizophrenia and bipolar disorder. Given its significant role in the central nervous system, NOS1AP has emerged as a potential therapeutic target for treating these mental health issues. Additionally, studies have shown that the protein can affect cellular calcium signaling and contribute to neuroinflammatory processes, further complicating its role in neurobiology. Understanding the structure and function of NOS1AP through the development of recombinant proteins could provide valuable insights into its mechanisms and interactions, paving the way for targeted therapies. Recombinant protein studies help elucidate the protein’s functional domains, offering a clearer understanding of how it modulates neuronal behavior and contributes to the pathophysiology of various brain disorders. Overall, NOS1AP represents a compelling focus for research aimed at deciphering the intricate relationships between genetic factors and neurological health.
