Analytical Data
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基因名
MCM9
- Application
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别名
(hMCM9)(Mini-chromosome maintenance deficient domain-containing protein 1)(Minichromosome maintenance 9)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NXL9
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表达区间
1-391aa
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分子量
48.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MCM9 (Minichromosome Maintenance Complex 9) is a key protein involved in DNA replication and repair processes, playing a crucial role in maintaining genomic stability. Research has shown that MCM proteins are essential for the initiation of DNA replication, and they form a part of the helicase complex that unwinds DNA strands, allowing replication machinery to access the genetic material. MCM9, in particular, is less studied compared to its MCM family counterparts, but emerging evidence suggests its involvement in DNA double-strand break repair and cellular responses to genotoxic stress. Mutations or dysregulation of MCM9 have been associated with various cancers, highlighting its potential as a biomarker for tumorigenesis and as a therapeutic target. The study of MCM9 recombinant proteins enables researchers to investigate its structural properties, functional mechanisms, and interactions with other proteins involved in the replication and repair pathways. Furthermore, understanding the role of MCM9 can provide insights into the development of novel cancer therapies and enhance our knowledge of the molecular underpinnings of DNA maintenance processes. Consequently, the research on MCM9 recombinant proteins is significant for elucidating the fundamental mechanisms of cell proliferation and survival, as well as for the advancement of therapeutic strategies aimed at combating cancer and other diseases associated with genomic instability.
