Analytical Data
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Gene name
GIF1
- Application
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Alternative Names
GRF1-interacting factor 1(AtGIF1)(Protein ANGUSTIFOLIA 3)(Transcription coactivator GIF1)
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Species
Arabidopsis thaliana
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Source
E. coli
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Tag
N- His-KSI
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8L8A5
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Expression Region
1-210aa
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Molecular Weight
37.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GIF1, or "G protein-coupled receptor-interacting factor 1," is a pivotal component in the study of cellular signaling mechanisms, particularly in relation to G protein-coupled receptors (GPCRs). GPCRs are integral membrane proteins that play crucial roles in various physiological processes by transmitting signals from outside the cell to the inside. The interest in GIF1 arises from its involvement in mediating the signaling pathways activated by GPCRs, influencing numerous biological functions, including cell growth, differentiation, and responses to external stimuli. Research has shown that GIF1 can interact with various G proteins, enhancing our understanding of how these complexes operate and their implications in health and disease. Abnormalities in GPCR signaling are linked to numerous pathologies, such as cancer, cardiovascular diseases, and neurological disorders, making GIF1 a significant target for therapeutic interventions. Investigating the structure and function of recombinant GIF1 protein not only provides insights into the fundamental aspects of cellular communication but also holds potential for drug development aimed at modulating GPCR-related pathways. Moreover, advancements in recombinant DNA technology have enabled the production of GIF1 in suitable expression systems, allowing for in-depth characterization of its properties and interactions, thereby fostering a growing body of knowledge that could inform innovative biomedical research and therapeutic strategies.
