Analytical Data
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Gene name
MSP-1
- Application
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Alternative Names
Merozoite surface antigens PMMSA p190
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Species
Plasmodium falciparum
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P04932
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Expression Region
937-1260aa
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Molecular Weight
40.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The MSP-1 protein, derived from the malaria parasite Plasmodium species, has garnered significant attention in malaria research due to its vital role in the parasite's life cycle and pathogenesis. MSP-1, or Merozoite Surface Protein 1, is expressed on the surface of merozoites, the invasive form of the parasite that enters red blood cells during infection. It is critical for parasite invasion and is also a key target for the host's immune response. Due to its abundance and accessibility during the blood stage of infection, MSP-1 is considered a promising candidate for malaria vaccine development. Research has focused on the protein's structure, function, and immunogenicity, with studies exploring how it elicits protective immunity in animal models and humans. Moreover, understanding the genetic diversity of MSP-1 across different Plasmodium strains provides insights into vaccine design and potential escape mechanisms of the parasite. Despite ongoing challenges, such as the complexity of the malaria life cycle and the antigenic variation of the MSP-1 protein, advances in molecular biology and immunology are paving the way for the development of effective malaria interventions aimed at reducing disease burden globally.
