Analytical Data
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Gene name
Tax
- Application
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Alternative Names
Protein X-LOR (Protein PX) (Trans-activating transcriptional regulatory protein of HTLV-1)
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Species
Human T-cell leukemia virus 1
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Source
E. coli
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Tag
N- His-SUMO & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P03409
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Expression Region
1-353aa
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Molecular Weight
55.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Tax proteins, particularly the Tax protein from Human T-cell Leukemia Virus type 1 (HTLV-1), have garnered significant interest in the field of molecular biology and cancer research due to their pivotal role in the pathogenesis of adult T-cell leukemia/lymphoma (ATLL). The Tax protein functions as a viral oncoprotein and exerts powerful effects on host cellular pathways, leading to the transformation of infected T-cells. Tax interacts with various cellular factors, hijacking signaling pathways such as NF-kB and AP-1, ultimately promoting cell proliferation and evasion of apoptosis. This capability makes Tax a crucial target for understanding the molecular mechanisms underpinning HTLV-1-associated malignancies. Moreover, Tax is instrumental in the complex interplay between the virus and the host immune response, leading to chronic inflammation and immune dysregulation. Researchers have also explored the potential of Tax proteins in developing novel therapeutic strategies, including vaccine design and gene therapy, aimed at combating HTLV-1 infections and associated cancers. The ongoing study of Tax proteins is essential for unraveling the intricacies of viral oncogenesis and may lead to breakthroughs in the treatment of HTLV-1-related diseases. Consequently, Tax proteins represent a fertile ground for research that merges virology, oncology, and immunology, underscoring their importance in both basic science and clinical applications.
