Analytical Data
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Gene name
GNAS
- Application
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Alternative Names
Adenylate cyclase-stimulating G alpha protein
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P63092
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Expression Region
1-394aa
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Molecular Weight
61.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GNAS, a gene encoding the alpha subunit of the stimulatory G protein, plays a crucial role in mediating cellular signaling pathways, particularly in response to hormones like parathyroid hormone (PTH) and thyroid-stimulating hormone (TSH). Mutations in GNAS can lead to various endocrine disorders, including pseudohypoparathyroidism and McCune-Albright syndrome, which are characterized by resistance to hormonal signals and abnormal tissue growth. The study of recombinant GNAS proteins has emerged as a vital avenue for understanding the structure-function relationship of GNAS and its interactions with various receptors and downstream effectors. By generating and purifying GNAS recombinant proteins, researchers can investigate the mechanisms of G protein activation and signaling, elucidate the effects of specific mutations, and develop potential therapeutic strategies. Additionally, recombinant GNAS proteins serve as valuable tools for drug discovery and the design of novel therapeutic agents targeting G protein-coupled receptor signaling pathways. Thus, GNAS recombinant protein research not only enhances our understanding of fundamental cellular processes but also has significant implications for treating related disorders.
