Analytical Data
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基因名
Elastase
- Application
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种属
Salmo salar
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7SIG3
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表达区间
1-236aa
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分子量
31.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Elastase is a serine protease primarily produced by neutrophils and plays a crucial role in the degradation of elastin and other extracellular matrix components. Its dysregulation is linked to various pathological conditions, such as emphysema, rheumatoid arthritis, and chronic obstructive pulmonary disease (COPD). Given its significant role in tissue remodeling and inflammation, elastase has become a target for therapeutic interventions. Research on recombinant elastase has gained traction, allowing for the production of this enzyme with specific mutations or modifications that enhance its stability and activity. Advances in genetic engineering, particularly with the use of techniques like CRISPR and various expression systems, have facilitated the generation of recombinant elastase for both basic research and potential clinical applications. By studying its structure and function, scientists aim to decipher the enzyme's precise mechanisms in disease processes, paving the way for the development of inhibitors that could mitigate its detrimental effects. Overall, recombinant elastase research not only contributes to our understanding of proteolytic enzymes in health and disease but also holds promise for innovative therapeutic strategies.
