Analytical Data
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基因名
LPAR3
- Application
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别名
Lysophosphatidic acid receptor Edg-7
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UBY5
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表达区间
298-353aa
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分子量
11.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LPAR3 (Lysophosphatidic Acid Receptor 3) is a G protein-coupled receptor that plays a significant role in various biological processes, including cell proliferation, migration, and survival. It is primarily activated by lysophosphatidic acid (LPA), a bioactive lipid involved in numerous pathophysiological conditions. Research has shown that LPAR3 is implicated in various diseases, including cancer, fibrosis, and neurological disorders, making it an attractive target for therapeutic interventions. The study of LPAR3-recombinant proteins is crucial for understanding its structure-function relationship, signaling mechanisms, and potential interactions with ligands. By generating and characterizing these recombinant proteins, researchers aim to elucidate the receptor's conformational states and downstream signaling pathways. Additionally, LPAR3's role in mediating cellular responses to LPA highlights the need for developing specific agonists or antagonists that could modulate its activity, thereby providing new avenues for treatment strategies in related diseases. Overall, the investigation of LPAR3-recombinant proteins serves as a foundation for advancing our comprehension of LPA signaling and its implications in health and disease.
