Analytical Data
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基因名
GSDMB
- Application
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别名
Gasdermin-like protein
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TAX9
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表达区间
1-411aa
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分子量
54.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GSDMB (Gasdermin B) is a member of the gasdermin family, which plays a critical role in pyroptosis, a form of programmed cell death associated with inflammation and immune responses. Recent studies have implicated GSDMB in various pathological conditions, including cancer, autoimmune diseases, and infectious diseases. Its ability to form pores in cellular membranes highlights its potential as a target for therapeutic intervention. The recombinant protein of GSDMB is being investigated to better understand its structure-function relationship and to elucidate its role in cellular processes. Furthermore, producing GSDMB as a recombinant protein allows researchers to explore its interactions with other proteins, post-translational modifications, and potential inhibitory mechanisms. Understanding these aspects of GSDMB not only contributes to the fundamental knowledge of cell death pathways but also opens avenues for developing novel strategies to manipulate immune responses in disease settings. Given the increasing evidence linking GSDMB to various diseases, recombinant protein studies may pave the way for innovative treatments and diagnostics.
