Analytical Data
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Gene name
MAP3K14
- Application
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Alternative Names
Serine/threonine-protein kinase NIK NF-kappa-beta-inducing kinase
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Species
Human
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99558
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Expression Region
400-655aa
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Molecular Weight
35.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP3K14, also known as MLK3 (Mixed-Lineage Kinase 3), is a member of the mitogen-activated protein kinase (MAPK) signaling cascade, which plays a critical role in various cellular processes, including proliferation, differentiation, and apoptosis. The protein is particularly involved in the activation of the c-Jun N-terminal kinase (JNK) pathway, linking external stress signals to intracellular responses. Research has indicated that dysregulation of MAP3K14 can contribute to numerous diseases, including cancer and neurodegenerative disorders. Given its pivotal role in mediating stress responses and cellular signaling, MAP3K14 has emerged as a promising target for therapeutic intervention. The study of recombinant MAP3K14 proteins allows for a deeper understanding of its functional mechanisms and interactions within the signaling pathways, facilitating the identification of small molecule inhibitors or modulators. Furthermore, understanding the structural characteristics of MAP3K14 through recombinant protein studies can pave the way for innovative drug design strategies, potentially leading to novel treatments for diseases linked to its dysregulation. As researchers continue to elucidate the role of MAP3K14 in various biological contexts, the development of recombinant forms of this protein offers valuable tools for both basic research and pharmaceutical applications.
