Analytical Data
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Gene name
KMT2E
- Application
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Alternative Names
Myeloid/lymphoid or mixed-lineage leukemia protein 5
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Species
Human
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Source
E. coli
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IZD2
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Expression Region
151-450aa
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Molecular Weight
42.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KMT2E, also known as MLL5, is a member of the MLL (mixed lineage leukemia) family of proteins, which are critical regulators of gene expression through their function as histone methyltransferases. KMT2E plays a pivotal role in epigenetic modulation by adding methyl groups to lysine 4 of histone H3 (H3K4), which is associated with transcriptional activation. Dysregulation of KMT2E has been implicated in various cancers, indicating its importance in maintaining cellular homeostasis and differentiation. Recent studies have shown that KMT2E may also interact with other chromatin-modifying complexes and transcription factors, suggesting that it could have broader implications in oncogenesis and developmental processes. Researchers are increasingly interested in the biochemical properties of KMT2E, including its enzymatic activity, structural features, and interaction partners, in order to elucidate its role in both normal physiology and disease. The generation of recombinant KMT2E proteins has become a vital tool for studying its function at a molecular level, leading to insights that may eventually inform therapeutic strategies targeting KMT2E-related pathways. As a result, understanding KMT2E is not only essential for comprehending its biological functions but also for developing potential interventions in diseases linked to its dysregulation, making the study of KMT2E recombinant proteins a significant area of research in epigenetics and cancer biology.
