Analytical Data
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基因名
HLA-DRB5
- Application
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别名
DR beta-5 DR2-beta-2 Dw2 MHC class II antigen DRB5
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q30154
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表达区间
30-227aa
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分子量
27.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HLA-DRB5 is a member of the human leukocyte antigen (HLA) class II beta chain family, which plays a crucial role in the immune response by presenting peptides to CD4+ T cells. It is particularly interesting because it exhibits genetic polymorphism and is associated with various autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. The study of recombinant HLA-DRB5 proteins is important for understanding its structure-function relationships, as well as for developing therapeutic strategies that could modulate immune responses. Recombinant proteins can be used to generate specific antibodies, study binding affinities with different peptides, and investigate their roles in disease pathogenesis. Moreover, as HLA-DRB5 is considered a key factor in shaping the immune response, research into its recombinant forms can provide insights into the mechanisms of antigen presentation and T cell activation. The exploration of HLA-DRB5 and its variants may also facilitate the identification of biomarkers for autoimmune disorders and improve our understanding of HLA-related disease susceptibility. Overall, the research on recombinant HLA-DRB5 not only advances our comprehension of the immune system's intricacies but also holds potential for novel therapeutic approaches in immunology and personalized medicine.
