Analytical Data
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Gene name
HLA-DRB5
- Application
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Alternative Names
DR beta-5 DR2-beta-2 Dw2 MHC class II antigen DRB5
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q30154
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Expression Region
30-227aa
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Molecular Weight
27.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HLA-DRB5 is a member of the human leukocyte antigen (HLA) class II beta chain family, which plays a crucial role in the immune response by presenting peptides to CD4+ T cells. It is particularly interesting because it exhibits genetic polymorphism and is associated with various autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. The study of recombinant HLA-DRB5 proteins is important for understanding its structure-function relationships, as well as for developing therapeutic strategies that could modulate immune responses. Recombinant proteins can be used to generate specific antibodies, study binding affinities with different peptides, and investigate their roles in disease pathogenesis. Moreover, as HLA-DRB5 is considered a key factor in shaping the immune response, research into its recombinant forms can provide insights into the mechanisms of antigen presentation and T cell activation. The exploration of HLA-DRB5 and its variants may also facilitate the identification of biomarkers for autoimmune disorders and improve our understanding of HLA-related disease susceptibility. Overall, the research on recombinant HLA-DRB5 not only advances our comprehension of the immune system's intricacies but also holds potential for novel therapeutic approaches in immunology and personalized medicine.
