Analytical Data
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基因名
LIPT1
- Application
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别名
Lipoate biosynthesis protein Lipoate-protein ligase Lipoyl ligase
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y234
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表达区间
26-373aa
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分子量
45.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LIPT1 (lipoyltransferase 1) is a crucial enzyme involved in the post-translational modification of mitochondrial proteins through the addition of lipoic acid, a cofactor essential for proper mitochondrial function and energy metabolism. Research into LIPT1 has gained significant attention due to its role in various biological processes and disease mechanisms. Dysfunction of LIPT1 has been implicated in metabolic disorders, neurodegenerative diseases, and certain types of cancer, prompting scientists to investigate its structure and function. The recombinant production of LIPT1 protein enables detailed biochemical studies, allowing researchers to dissect its enzymatic mechanism and interactions with substrate proteins. Understanding LIPT1's role can reveal insights into mitochondrial biology and potentially lead to novel therapeutic strategies for diseases associated with mitochondrial dysfunction. The development of efficient expression systems for LIPT1 and the exploration of its enzymatic properties are critical steps in elucidating its biological significance and therapeutic potential.
