Analytical Data
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基因名
isdB
- Application
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别名
Fur-regulated protein B Staphylococcal iron-regulated protein H Staphylococcus aureus surface protein J
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种属
Staphylococcus aureus
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P0C7J5
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表达区间
41-269aa
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分子量
41.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IsdB, or Iron-regulated surface determinant B, is a key protein associated with the virulence of certain pathogens, notably Staphylococcus aureus. This protein plays a crucial role in iron acquisition, which is vital for bacterial survival and pathogenicity, especially in iron-limited environments such as the human host. Research into the structure and function of IsdB has garnered attention due to its potential as a target for new therapeutic strategies. Understanding the molecular mechanisms of IsdB can provide insights into bacterial iron metabolism and the development of vaccine candidates. Furthermore, studies on IsdB have revealed its involvement in the formation of biofilms and its role in evading the host's immune response, making it a significant focus for developing strategies to combat bacterial infections. The pursuit of recombinant IsdB proteins also opens avenues for studying protein interactions and the design of inhibitors that could mitigate infection, representing a promising area of research in microbiology and infectious diseases.
