Analytical Data
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Gene name
KAT14
- Application
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Alternative Names
ADA2A-containing complex subunit 2 CRP2-binding partner Lysine acetyltransferase 14
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H8E8
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Expression Region
1-782aa
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Molecular Weight
94.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KAT14 is a histone acetyltransferase that plays a crucial role in regulating gene expression and chromatin dynamics through lysine acetylation of histone proteins. Its involvement in essential cellular processes such as transcriptional activation and DNA repair has made it a significant focus of epigenetic research. Historically, the dysregulation of KAT14 has been linked to various diseases, particularly cancers, where altered acetylation patterns contribute to the aberrant expression of oncogenes and tumor suppressor genes. Recent studies have highlighted the potential of KAT14 as a therapeutic target, with the development of specific inhibitors aimed at modulating its activity to restore normal acetylation levels and reverse disease progression. Given its pivotal function in the epigenetic landscape, understanding the mechanisms underlying KAT14's action could pave the way for innovative treatments that harness the power of epigenetics to combat diseases driven by aberrant gene regulation. By investigating the structure-function relationship of KAT14 and its interactions within the chromatin environment, researchers aim to elucidate its precise role in cellular physiology and its potential implications in therapeutic applications.
