Analytical Data
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基因名
lon
- Application
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别名
ATP-dependent protease La
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种属
Mycoplasma pneumoniae
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P78025
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表达区间
1-206aa
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分子量
39.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LON protease, a key member of the ATP-dependent protease family, is an essential mitochondrial enzyme in eukaryotic cells that plays a critical role in maintaining mitochondrial protein homeostasis. It participates in the degradation of misfolded or damaged proteins, thus preventing the accumulation of toxic substrates that could compromise mitochondrial function and cellular health. The dysfunction of LON protease has been implicated in various pathologies, including neurodegenerative diseases, cancer, and aging-related disorders. Research into LON protease has gained momentum due to its dual role in protein quality control and regulatory functions in mitochondrial dynamics. Recent studies have focused on understanding the structural features of LON, its substrate specificity, and the mechanistic aspects of how it recognizes and unfolds substrates for degradation. The modulation of LON activity presents a promising therapeutic avenue for enhancing mitochondrial function and combating diseases associated with mitochondrial stress. Furthermore, insights into LON's interactions with other mitochondrial chaperones and proteases are crucial for delineating its role within the cellular proteolytic landscape, thereby offering potential targets for drug development aimed at restoring mitochondrial health and improving therapeutic outcomes in related diseases.
