Analytical Data
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Gene name
CNTNAP2
- Application
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Alternative Names
Cell recognition molecule Caspr2
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Species
Pongo abelii
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5RD64
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Expression Region
35-181aa
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Molecular Weight
20.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CNTNAP2 (Contactin-Associated Protein 2) is a gene located on chromosome 7 that encodes for a protein crucial in neuronal development and functioning, particularly in the formation of the axon-glia complex, which is essential for maintaining neuronal integrity and facilitating signal transmission. Variations and mutations in the CNTNAP2 gene have been linked to various neurodevelopmental disorders, including autism spectrum disorder (ASD), specific language impairment (SLI), and schizophrenia. Given its significant role in neural connectivity and synaptic functioning, CNTNAP2 has become a focal point in understanding the genetic underpinnings of these disorders. Research on recombinant CNTNAP2 protein aims to elucidate its structure, function, and interaction with other neuronal proteins, potentially revealing mechanisms of action that contribute to neurodevelopmental pathologies. By producing and studying this recombinant protein, scientists can investigate its role in cellular processes, such as adhesion, signaling, and axonal transport, and assess how disruptions in its function may lead to the manifestations of various neurodevelopmental conditions. Insights gained from these studies might inform therapeutic strategies targeting CNTNAP2-related pathways and assist in the development of interventions aimed at ameliorating cognitive and communicative deficits associated with neurodevelopmental disorders. Ultimately, understanding the multifaceted roles of CNTNAP2 through recombinant protein research holds promise for advancing our comprehension of neurodevelopmental health and disease.
