Analytical Data
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Gene name
DYNC1I1
- Application
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Alternative Names
Cytoplasmic dynein intermediate chain 1 Dynein intermediate chain 1, cytosolic
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Species
Human
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Source
Baculovirus
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14576
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Expression Region
1-645aa
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Molecular Weight
75.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DYNC1I1, or Dynein Cytoplasmic 1 Intermediate Chain 1, is a crucial component of the cytoplasmic dynein motor complex, which is essential for various cellular processes including intracellular transport, organelle positioning, and cell division. The dynein complex is responsible for retrograde transportation along microtubules, facilitating the movement of cellular components such as vesicles, organelles, and protein complexes toward the cell center. Recent studies have highlighted the significance of DYNC1I1 in neurodegenerative diseases and cellular dysfunctions, suggesting that mutations or dysregulation of this protein can contribute to disease pathogenesis. As a result, researchers are focusing on the structural and functional characterization of DYNC1I1 to better understand its role in cellular dynamics and its potential as a therapeutic target. Recombinant DYNC1I1 proteins are being produced to investigate their interactions with other dynein subunits and cellular partners, with the aim of elucidating the mechanisms of dynein-mediated transport and identifying potential small-molecule modulators. This research is not only pivotal for deciphering fundamental biological processes but also holds promise for developing interventions in diseases linked to dynein dysfunction.
