Analytical Data
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Gene name
RO60
- Application
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Alternative Names
Ro 60KDA autoantigen;Sjoegren syndrome antigen A2Sjoegren syndrome type A antigen ;SS-ATROVE domain family member 2
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P10155
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Expression Region
3-535aa
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Molecular Weight
64.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RO60 is a protein that plays a pivotal role in the immune response and has garnered attention due to its involvement in various autoimmune diseases, particularly systemic lupus erythematosus (SLE). As a key component of the Ro ribonucleoprotein complex, RO60 is known to interact with small RNA molecules, influencing the stability and processing of these RNAs, which are critical for cellular function. Research has shown that antibodies against RO60 are prevalent in patients with SLE, indicating its potential as a biomarker for disease diagnosis and progression. Furthermore, RO60's involvement in immune regulation highlights its significance in understanding the mechanisms underlying autoimmunity. Recent studies have expanded the investigation into RO60's structural characteristics and its molecular interactions, aiming to explore potential therapeutic targets that could modulate its activity. The importance of RO60 in immune system dysregulation emphasizes the need for continued research to elucidate its precise role and to develop novel approaches for managing autoimmune conditions where RO60 is implicated.
