Analytical Data
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基因名
TIMM8A
- Application
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别名
Deafness dystonia protein 1 X-linked deafness dystonia protein
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60220
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表达区间
1-97aa
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分子量
38 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIMM8A, a mitochondrial import protein, plays a crucial role in the translocation of proteins into mitochondria, which are essential for cellular energy production and overall cellular metabolism. Mutations in the TIMM8A gene are associated with a rare neurological disorder known as Möbius syndrome, characterized by facial paralysis and other motor impairments. Researchers have been focusing on TIMM8A to understand its functional mechanisms and its interactions with other mitochondrial proteins. The investigation of TIMM8A is particularly important as it provides insights into mitochondrial dysfunctions, which are implicated in a variety of diseases, including neurodegenerative disorders and metabolic syndromes. Recent advances in biotechnology, including recombinant protein expression techniques, have facilitated the production of TIMM8A in model systems, allowing for more detailed studies of its structure and function. This research aims to elucidate the role of TIMM8A in mitochondrial protein import pathways and its potential implications in health and disease, thereby paving the way for therapeutic strategies targeting mitochondrial dysfunctions. By exploring the dynamics of TIMM8A, scientists hope to uncover novel insights into mitochondrial biology and its significance in overall cellular health, providing a foundation for future investigations in related fields.
