Analytical Data
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基因名
TIMM17B
- Application
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别名
DXS9822; Inner mitochondrial membrane preprotein translocase; JM3; Mitochondrial import inner membrane translocase subunit Tim17-B; TI17B_HUMAN; Tim17b; TIMM17B; Translocase of inner mitochondrial membrane 17 homolog B (yeast)
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60830
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表达区间
1-172aa
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分子量
45.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIMM17B (Translocase of Inner Mitochondrial Membrane 17B) is a key component of the mitochondrial protein import machinery, playing a critical role in the translocation of nuclear-encoded proteins into the mitochondria. Mitochondria are essential organelles responsible for energy production, and their dysfunction is implicated in various diseases, including neurodegenerative disorders, metabolic syndromes, and cancer. Research into TIMM17B has gained momentum as it contributes to understanding mitochondrial dynamics and the pathophysiology of these diseases. The study of TIMM17B, including its structural characteristics and interactions with other mitochondrial proteins, can provide insights into the molecular mechanisms behind mitochondrial import processes. Moreover, mutations or dysregulation of TIMM17B have been associated with mitochondrial diseases, underscoring its importance in maintaining mitochondrial function and cellular homeostasis. Investigating TIMM17B through recombinant protein studies can facilitate the development of therapeutic strategies aimed at mitigating the impact of mitochondrial dysfunction. Overall, TIMM17B serves as a promising target for research aimed at unraveling the complexities of mitochondrial biology and its links to human health and disease.
