Analytical Data
-
Gene name
TIMM23
- Application
-
Alternative Names
TIMM23; TIM23; Mitochondrial import inner membrane translocase subunit Tim23
-
Species
Human
-
Source
E. coli
-
Tag
N- GST
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
O14925
-
Expression Region
1-209aa
-
Molecular Weight
48.9 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The TIMM23 (Translocase of Inner Mitochondrial Membrane 23) protein is a crucial component of the mitochondrial protein translocation machinery, facilitating the import of precursor proteins into the mitochondria, an essential process for maintaining mitochondrial function and cellular energy production. Research into TIMM23 has gained momentum due to its vital role in mitochondrial biogenesis and homeostasis, which are pivotal for various physiological processes. Dysfunctional TIMM23 has been implicated in several mitochondrial disorders and diseases, including neurodegenerative conditions and metabolic syndromes. Understanding the structural and functional characteristics of TIMM23 through recombinant protein studies is critical for elucidating its mechanism of action and potential interactions with other mitochondrial proteins. The reconstitution of TIMM23 in vitro enables researchers to investigate its protein folding, transport dynamics, and interactions, providing insights into the larger context of mitochondrial protein import. This research is particularly significant in the realm of therapeutic development, as targeting TIMM23 pathways may offer new strategies for addressing mitochondrial dysfunction-related diseases. Overall, TIMM23 serves as a key player in mitochondrial integrity, and continued studies on its recombinant protein are essential for advancing our knowledge of mitochondrial biology and potential therapeutic interventions.
