Analytical Data
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基因名
PSMB8
- Application
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别名
Low molecular mass protein 7 Macropain subunit C13 Multicatalytic endopeptidase complex subunit C13 Proteasome component C13 Proteasome subunit beta-5i Really interesting new gene 10 protein
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P28062
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表达区间
73-276aa
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分子量
42.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMB8, a member of the proteasome subunit beta type family, plays a critical role in the proteolytic processing of ubiquitinated proteins, thus contributing to the regulation of various cellular processes, including the removal of damaged proteins and the presentation of antigens to the immune system. Research into PSMB8 has gained traction due to its association with several diseases, particularly in the context of immune disorders and cancer. In particular, mutations or dysregulation of PSMB8 have been linked to specific forms of autoimmune diseases such as SLE (Systemic Lupus Erythematosus) and certain malignancies, thereby underscoring its importance in maintaining cellular homeostasis and immune function. Advances in recombinant protein technology have facilitated the production and study of PSMB8, allowing researchers to elucidate its structure-function relationships and explore its potential as a therapeutic target. Understanding the mechanistic pathways involving PSMB8 not only aids in delineating its role in health and disease but also opens avenues for the development of innovative treatment strategies aimed at modulating its activity or compensating for its dysfunction in various pathological conditions. The ongoing exploration of PSMB8’s functions and interactions continues to provide valuable insights into the complexities of intracellular protein degradation and its implications for human health.
