Analytical Data
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基因名
NDUFA6
- Application
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别名
Complex I-B14 ;CI-B14LYR motif-containing protein 6NADH-ubiquinone oxidoreductase B14 subunit
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56556
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表达区间
27-154aa
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分子量
42.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NDUFA6, a subunit of the mitochondrial NADH:ubiquinone oxidoreductase complex I, plays a crucial role in cellular respiration by facilitating the transfer of electrons from NADH to the electron transport chain. The dysfunction of complex I has been linked to various mitochondrial diseases, neurodegenerative disorders, and metabolic syndromes, highlighting the significance of NDUFA6 in maintaining mitochondrial integrity and energy production. Recent studies have focused on characterizing the structure and function of NDUFA6, as well as its interactions with other complex I subunits and ancillary proteins. Recombinant NDUFA6 protein has emerged as a vital tool for understanding the mechanistic pathways of complex I assembly and activity. By producing this protein in a controlled environment, researchers can investigate its biochemical properties, mutant variants associated with disease, and potential therapeutic interventions. The pursuit of NDUFA6 recombinant protein also aids in the development of high-throughput screening methods for identifying small molecules that could restore normal function to complex I in affected patients. Overall, the study of NDUFA6 and its recombinant form offers promising insights into mitochondrial biology and potential avenues for therapeutic advancements in mitochondrial-related diseases.
