Analytical Data
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基因名
ERCC5
- Application
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别名
DNA excision repair protein ERCC-5 Xeroderma pigmentosum group G-complementing protein
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P28715
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表达区间
947-1186aa
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分子量
30.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ERCC5, also known as XPG, is a crucial gene involved in the nucleotide excision repair (NER) pathway, which is essential for repairing DNA damage caused by environmental factors such as UV radiation and chemical mutagens. Mutations in the ERCC5 gene can lead to several disorders, most notably xeroderma pigmentosum (XP), a condition characterized by extreme sensitivity to sunlight and a significantly increased risk of skin cancer. Understanding the function and regulation of ERCC5 is critical for elucidating the mechanisms of DNA repair and its role in maintaining genomic stability. Recently, research efforts have focused on the recombinant expression of the ERCC5 protein, allowing scientists to study its structure, function, and interactions with other proteins in detail. These studies employ various biophysical techniques to examine the protein's enzymatic activity and its role in DNA repair processes. Additionally, by generating recombinant ERCC5, researchers can explore potential therapeutic strategies for diseases linked to NER deficiencies. This research not only has implications for understanding the molecular basis of certain genetic disorders but also paves the way for developing targeted treatments that enhance DNA repair mechanisms, ultimately offering hope for patients affected by conditions related to impaired DNA repair pathways.
