Analytical Data
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基因名
EPPK1
- Application
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别名
450KDA epidermal antigen
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P58107
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表达区间
1-225aa
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分子量
27.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EPPK1 (epidermal growth factor receptor pathway substrate 15, also known as Eps15 homology domain-containing protein 1) is a key protein involved in various cellular processes, including signal transduction, cell growth, and differentiation. Its function is primarily linked to the epidermal growth factor receptor (EGFR) pathway, which plays a critical role in cell proliferation and survival. Dysregulation of this pathway is often associated with several cancers, making EPPK1 an important target for therapeutic intervention. Research has shown that EPPK1 can influence the internalization and degradation of EGFR, thereby modulating downstream signaling events. Despite its significance, the structural and functional details of EPPK1 remain inadequately understood, prompting the need for its recombinant protein study. Characterizing EPPK1 through recombinant technology enables the generation of large quantities of pure protein, facilitating biochemical and biophysical analyses. Such studies are essential for elucidating its mechanism of action and potential implications in cancer biology, as well as for identifying new drug targets. The development of EPPK1 as a recombinant protein offers valuable insights into its role in cellular signaling and pathophysiology, laying the groundwork for novel therapeutic strategies aimed at managing diseases linked to the EGFR signaling pathway.
