Analytical Data
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基因名
DAOA
- Application
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别名
Protein G72
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P59103
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表达区间
1-153aa
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分子量
45.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DAOA (D-amino acid oxidase activator) is a protein that has garnered significant interest in the field of neuroscience due to its potential implications in mental health and neurodevelopmental disorders. Research shows that alterations in D-amino acid metabolism can influence neurotransmission, particularly through the modulation of glutamate signaling in the brain. The DAOA protein is believed to play a critical role in this process by enhancing the activity of D-amino acid oxidase (DAO), an enzyme involved in the degradation of D-serine, a crucial co-agonist of the NMDA receptor. Dysregulation of this pathway has been associated with various psychiatric conditions, including schizophrenia, bipolar disorder, and depression. Studies have also suggested that genetic variations in the DAOA gene may contribute to individual susceptibility to these disorders. Consequently, researchers are exploring DAOA’s structural properties and functional mechanisms to understand its role in neurobiology further. Investigating the potential of DAOA as a therapeutic target may lead to novel interventions for treating mental illnesses, emphasizing the importance of understanding this protein’s biology in developing effective treatment strategies. Overall, the study of DAOA and its interactions with other biochemical pathways represents a promising frontier in mental health research.
