Analytical Data
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基因名
CYP2C8
- Application
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别名
CYPIIC8 (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase)
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P10632
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表达区间
27-490aa
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分子量
60.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CYP2C8, a member of the cytochrome P450 family, plays a crucial role in drug metabolism and is primarily involved in the oxidation of various xenobiotics and endogenous compounds. Understanding CYP2C8 function is essential for predicting drug interactions, metabolite formation, and individual variability in drug responses. Genetic polymorphisms and environmental factors can significantly affect CYP2C8 activity, leading to altered pharmacokinetics and increased risk of adverse drug reactions. Research has focused on the recombinant expression of CYP2C8 to facilitate detailed studies of its enzymatic properties, substrate specificity, and interaction with inhibitors or inducers. Advances in recombinant protein technology have enabled the production of CYP2C8 in heterologous systems, providing insights into its structural and functional aspects. Furthermore, studies on CYP2C8 have implications in personalized medicine, as understanding its variability can aid in optimizing drug dosing and minimizing toxicity for patients with different genetic backgrounds. Overall, the investigation of CYP2C8 recombinant protein is vital for enhancing the understanding of metabolic pathways and improving the safety and efficacy of therapeutic interventions.
