Analytical Data
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基因名
CREB1
- Application
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别名
Active transcription factor CREB; cAMP response element binding protein 1; cAMP response element binding protein; cAMP responsive element binding protein 1; cAMP-responsive element-binding protein 1; CREB; CREB-1; CREB1; CREB1_HUMAN; Cyclic AMP-responsive element-binding protein 1; MGC9284; OTTHUMP00000163864; OTTHUMP00000163865; OTTHUMP00000206660; OTTHUMP00000206662; OTTHUMP00000206667; Transactivator protein
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P16220
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表达区间
1-341aa
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分子量
40.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CREB1 (cAMP response element-binding protein 1) is a transcription factor that plays a pivotal role in various cellular processes, including cell proliferation, differentiation, and survival. It is critical in the regulation of gene expression in response to extracellular signals, particularly those mediated by cyclic adenosine monophosphate (cAMP) and other signaling pathways. The importance of CREB1 has been highlighted in numerous studies associating its dysregulation with various pathological conditions, including cancer, neurodegenerative diseases, and metabolic disorders. Given its central role in numerous biological functions, there has been increasing interest in the creation and utilization of recombinant CREB1 proteins for research. Such recombinant proteins are essential for studying the structure-function relationships of CREB1, identifying and characterizing its interaction with other proteins, and understanding how its activity is regulated at the molecular level. Additionally, the availability of CREB1 recombinant proteins facilitates the exploration of potential therapeutic strategies to modulate its function in disease contexts, offering insights into the development of novel treatments targeting CREB1-related pathways. Therefore, research on CREB1 recombinant proteins is not only fundamental for basic science but also holds significant potential for translational applications in medicine.
