Analytical Data
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基因名
AES
- Application
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别名
Gp130-associated protein GAM Grg-5 Groucho-related protein 5 Protein ESP1 Protein GRG
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q08117
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表达区间
1-264aa
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分子量
56.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of AES (Anti-Estrogen in Breast Cancer) reprogramming proteins has gained significant attention in recent years due to their potential roles in cellular regulation and cancer therapeutics. AES is a member of the myc network, primarily implicated in the repression of myogenic genes and modulation of cellular differentiation. Research has revealed that AES can act as a transcriptional co-repressor, engaging with various nuclear receptors and interacting with other proteins that modulate gene expression. These interactions are crucial in understanding the complex mechanisms of hormone signaling pathways, particularly in breast cancer where estrogen plays a pivotal role. The reprogramming aspect refers to the ability of AES to influence cell fate decisions, potentially altering the differentiation pathways of malignant cells. Given the increasing prevalence of breast cancer, elucidating the function of AES could provide insights into novel therapeutic strategies that target hormonal receptors or pathways dysregulated in tumors. Therefore, ongoing studies are exploring the molecular mechanisms by which AES regulates gene expression and its implications in tumor biology, with the hope of uncovering new targets for intervention in cancer treatment and prevention.
