Analytical Data
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基因名
ADH1B
- Application
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别名
Alcohol dehydrogenase subunit beta
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P00325
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表达区间
2-375aa
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分子量
55.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADH1B, or alcohol dehydrogenase class I beta, is an important enzyme involved in the metabolism of ethanol and other substrates in the liver. Variants of the ADH1B gene, particularly the ADH1B*2 allele, have been associated with variations in alcohol metabolism and susceptibility to alcohol-related disorders. Research has shown that individuals carrying the ADH1B*2 variant experience a higher rate of ethanol oxidation, leading to increased levels of acetaldehyde, a toxic byproduct of alcohol metabolism. This heightened metabolic response appears to protect these individuals from the effects of excessive alcohol consumption, thereby reducing the incidence of alcohol dependence and related health issues. Studies on recombinant ADH1B proteins facilitate the exploration of the enzyme's kinetic properties and mechanisms of action, allowing researchers to understand the structural and functional basis of its activity. These insights have implications not only for alcohol metabolism but also for drug metabolism and the development of therapeutic strategies targeting alcohol use disorders. Understanding the role of ADH1B in different populations can provide valuable data for personalized medicine approaches, where genetic factors can inform treatment decisions and risk assessments for alcohol-related conditions. Consequently, the study of ADH1B recombinant proteins has become a critical focus in biochemistry, pharmacology, and public health research.
