Analytical Data
-
基因名
PSENEN
- Application
-
别名
Presenilin enhancer protein 2 (PEN2)
-
种属
Human
-
表达系统
E. coli
-
标签
N- His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9NZ42
-
表达区间
1-101aa
-
分子量
14.8 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PSENEN (Presenilin Enhancer 2) is a crucial protein associated with the regulation of gamma-secretase, an enzyme complex involved in the cleavage of membrane proteins, including the amyloid precursor protein (APP). This process is integral to the production of amyloid-beta peptides, which are implicated in the pathogenesis of Alzheimer’s disease. Mutations in genes related to gamma-secretase, including PSEN1, PSEN2, and APP, have been linked to familial forms of the disease. Research on PSENEN focuses on its role as a vital co-factor for gamma-secretase activity, influencing substrate processing and stability of the complex. Understanding PSENEN's function can provide insights into the pathways leading to neurodegeneration and the development of therapeutic strategies aimed at modulating gamma-secretase activity to mitigate the accumulation of harmful amyloid-beta. Recent studies employing recombinant PSENEN proteins have facilitated the exploration of its structural characteristics and interactions within the gamma-secretase complex, revealing potential targets for drug development. Additionally, PSENEN's involvement in various cellular processes, including cell signaling and apoptosis, highlights its significance beyond Alzheimer's disease pathology, making it a compelling subject for further investigation in neurobiology and therapeutic innovation.
