Analytical Data
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基因名
HTR3E
- Application
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别名
Serotonin receptor 3E
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A5X5Y0
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表达区间
72-228aa&241-456aa
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分子量
58.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HTR3E is a crucial component of the 5-hydroxytryptamine (serotonin) receptor family, specifically the 5-HT3 receptor subtype. This receptor is a ligand-gated ion channel that plays a significant role in neurotransmission and is implicated in various physiological and pathological processes, including anxiety, depression, and gastrointestinal functioning. Research on HTR3E focuses on its role in modulating neuronal excitability and synaptic transmission, making it a potential target for therapeutic interventions. Recombination technology has been utilized to produce HTR3E proteins for in-depth studies, facilitating the investigation of its structural and functional properties. Characterizing the recombinant HTR3E protein can help elucidate the mechanism of receptor activation and desensitization, as well as the effects of different ligands and pharmacological agents. Understanding HTR3E's function may also lead to the development of novel drugs to address serotonin-related disorders, contributing significantly to the fields of neuroscience and psychopharmacology. Recent studies have underscored the receptor's complexity, highlighting the influence of genetic variations and potential drug interactions, which further emphasizes the need for continued research into HTR3E and its implications for mental health and gastrointestinal treatments.
