Analytical Data
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Gene name
ALOX5AP
- Application
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Alternative Names
FLAP MK-886-binding protein
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P20292
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Expression Region
1-161aa
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Molecular Weight
34.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ALOX5AP, or Arachidonate Lipoxygenase 5-Activating Protein, is a key player in the regulation of inflammatory processes and leukotriene biosynthesis, which are essential in various pathological conditions such as asthma, atherosclerosis, and other inflammatory diseases. The protein facilitates the activity of 5-lipoxygenase (5-LO), an enzyme critical for the conversion of arachidonic acid into leukotrienes, potent mediators of inflammation. Research on ALOX5AP has gained momentum due to its potential as a therapeutic target for modulating inflammatory responses. Understanding the structure and function of this protein through recombinant protein studies enables researchers to explore its enzymatic mechanisms, protein interactions, and role in signaling pathways. Additionally, the development of ALOX5AP inhibitors may pave the way for novel anti-inflammatory treatments. Given the increasing incidence of inflammatory diseases worldwide, studying this protein not only provides insights into fundamental biochemical processes but also holds promise for advancing novel clinical interventions.
