Analytical Data
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基因名
Contactin-2/CNTN2
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简介
The Contactin-2/CNTN2 protein, together with CNTNAP2, organizes axonal domains at the nodes of Ranvier and maintains voltage-gated potassium channels in the proximal paranodal region. This partnership ensures axonal signaling integrity and function. Contactin-2/CNTN2 Protein, Human (HEK293, His) is the recombinant human-derived Contactin-2/CNTN2 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
rHuContactin-2/CNTN2, His ; Contactin-2; Axonal glycoprotein TAG-1; Axonin-1; Transient axonal glycoprotein 1; CNTN2; AXT; TAG1; TAX1
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q02246
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表达区间
S31-N1012
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氨基酸序列
SQTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGTSMMVEN
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蛋白长度
Full Length of Mature Protein
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分子量
110-140 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Contactin-2 (CNTN2) is a member of the contactin family, which plays a crucial role in the development and function of the nervous system. It is a glycosylphosphatidylinositol (GPI)-anchored protein found on the surface of neurons and is involved in axon-glial interactions, myelination, and synaptic function. Research has shown that CNTN2 interacts with various neuronal cell types and extracellular matrix components, influencing neuronal adhesion, migration, and signaling pathways. Abnormal expression or dysfunction of CNTN2 has been linked to several neurological disorders, including autism spectrum disorders, schizophrenia, and multiple sclerosis. Therefore, the recombinant expression of CNTN2 is of great interest for both basic neuroscience research and potential therapeutic applications. By producing a functional CNTN2 protein through recombinant biotechnology, researchers can study its role in cell adhesion and signaling, investigate its molecular interactions, and explore its potential as a biomarker or target for neurodevelopmental and neurodegenerative diseases. Understanding the precise mechanisms of CNTN2 may offer insights into its contributions to neuronal health and disease, paving the way for novel interventions in neurobiology.
