Analytical Data
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基因名
CLIC4/Chloride intracellular channel 4
- Application
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别名
H1; CLIC4L; huH1; p64H1; Intracellular chloride ion channel protein p64H1
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y696
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表达区间
Tyr104~Lys253
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分子量
47kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Chloride intracellular channel 4 (CLIC4) is a member of the CLIC family of proteins that play crucial roles in various cellular processes, including regulation of cell volume, intracellular chloride ion homeostasis, and cellular signaling pathways. CLIC4 is unique among its family members because it can exist in both soluble and membrane-bound forms, allowing it to participate in diverse cellular functions located in different compartments. Research has shown that CLIC4 is implicated in cancer progression, including tumor growth and metastasis, as well as roles in other pathophysiological conditions such as cardiac and neurodegenerative diseases. The study of recombinant CLIC4 protein can provide insights into its structural characteristics, functional mechanisms, and interactions with other proteins. Understanding these aspects can reveal the potential of CLIC4 as a therapeutic target or biomarker in diseases where chloride channel dysregulation occurs. The recombinant production of CLIC4 enables detailed biochemical and biophysical analyses, facilitating the development of inhibitors or modulators that could alter CLIC4 function and potentially offer new strategies for disease intervention. Given the importance of chloride channels in maintaining cellular homeostasis and the emerging roles of CLIC4 in various diseases, continued research into this protein is essential for elucidating its contributions to both normal physiology and pathological conditions.
