Analytical Data
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Gene name
NTS1/NTSR1
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简介
NTS1/NTSR1 protein, as the receptor for neurotensin, regulates fat metabolism through potential endocrine and paracrine functions. The neuropeptide exerts influence on smooth muscle contraction. NTS1/NTSR1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived NTS1/NTSR1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
NT; NTR; NTR1; NTRH; NTRR; NTS1; NTSR1; NMN-125; NN; NT/N; NTS
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Species
Cynomolgus
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q2PG57
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Expression Region
S24-L163
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Protein Length
Partial
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Molecular Weight
20-25 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NTS1 (Neurotensin receptor 1) is a G protein-coupled receptor that binds neurotensin, a neuropeptide involved in various physiological processes, including pain modulation, appetite regulation, and neuroendocrine functions. Understanding the structural and functional properties of NTS1 is vital for elucidating its roles in both normal and pathological conditions, such as obesity, schizophrenia, and certain cancers. The recombinant production of NTS1/NTSR1 proteins offers a valuable tool for researchers aiming to investigate receptor-ligand interactions, signaling pathways, and potential therapeutic targets. Utilizing techniques like site-directed mutagenesis, researchers can generate variants of NTS1 to study the effects of specific amino acids on receptor activity. Moreover, the expression of NTS1 in heterologous systems, such as insect or mammalian cell lines, enables high-yield production and facilitates subsequent biophysical analyses, including crystallography and spectroscopy. Advances in the field of structural biology have further propelled the exploration of NTS1, offering insights into its three-dimensional conformation and binding dynamics. This knowledge not only enhances our understanding of receptor pharmacology but also aids in the design of selective modulators that may have significant clinical implications. As research continues to unravel the complexities of NTS1 signaling, the development of novel therapeutic strategies targeting this receptor holds promise for treating various disorders linked to neurotensin dysregulation.
