Analytical Data
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基因名
CD146/MCAM
- Application
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别名
MCAM; MUC18; Melanoma Cell Adhesion Molecule; Cell surface glycoprotein P1H12; Melanoma-associated antigen A32; S-endo 1 endothelial-associated antigen
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种属
Rat
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9EPF2
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表达区间
Gln323~Lys560
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分子量
34kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD146, also known as MCAM (Melanoma Cell Adhesion Molecule), is a cell adhesion molecule that plays a critical role in various physiological and pathological processes, including angiogenesis, immune response, and tumor metastasis. Identified initially in melanoma cells, CD146 is expressed in endothelial cells, smooth muscle cells, and a variety of other tissues, which suggests its involvement in both normal and diseased states. Research has demonstrated that CD146 is implicated in the regulation of cell-matrix interactions, influencing cell signaling pathways that govern proliferation and migration. Its role in cancer biology has garnered significant interest, as elevated CD146 expression has been associated with increased metastatic potential and poor prognosis in several tumor types. Consequently, the development of CD146/MCAM recombinant proteins has become a focal point for investigating its functions and interactions. These proteins serve as valuable tools for both in vitro and in vivo studies, allowing researchers to explore the molecular mechanisms underlying CD146-mediated cellular processes. Furthermore, therapeutic approaches targeting CD146 are being investigated, given its potential as a biomarker for cancer diagnosis and prognosis, as well as a target for novel cancer therapies. Understanding the precise roles and mechanisms of CD146/MCAM through the use of recombinant proteins is essential for advancing our knowledge of its contributions to human health and disease.
