Analytical Data
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基因名
SIRP gamma
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简介
SIRP γ protein is a possible immunoglobulin-like cell surface receptor that mediates cell-cell adhesion by binding to CD47. This interaction enhances antigen-specific T cell proliferation and provides costimulatory signals for T cell activation, highlighting the role of SIRP gamma in regulating immune responses. SIRP gamma Protein, Human (HEK293, His-Avi) is the recombinant human-derived SIRP gamma protein, expressed by HEK293 , with C-His, C-Avi labeled tag.
- Application
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别名
CD172g; FLJ42230; SIRP beta 2; SIRP gamma; SIRP-B2; SIRPG; Cripto-1; bA77C3.1; SIRP β 2
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9P1W8-1
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表达区间
E29-P360
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蛋白长度
Extracellular Domain
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分子量
45-52 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SIRP gamma (Signal Regulatory Protein gamma) is a member of the SIRP family, which plays critical roles in immune regulation and cellular signaling. These proteins are known to interact with CD47, a widely expressed "don't eat me" signal on cell surfaces, thus regulating macrophage activity and immune responses. SIRP gamma specifically is expressed in various immune cells and is implicated in the modulation of T-cell activity, dendritic cell function, and overall immune homeostasis. The study of SIRP gamma, particularly its recombinant forms, offers insights into its structural and functional characteristics, which may have therapeutic implications for enhancing immune responses in cancer therapy and improving outcomes in infectious diseases. Recent advancements in protein engineering techniques have enabled the production of SIRP gamma as a recombinant protein, allowing researchers to investigate its binding properties, signaling pathways, and potential as a drug target. Understanding the mechanisms by which SIRP gamma influences immune cell interactions can reveal novel strategies for manipulating the immune system in clinical settings, particularly in devising effective immunotherapies and vaccines. As immune evasion is a significant hurdle in cancer treatment, uncovering the role of SIRP gamma could lead to innovative approaches to reinvigorate the immune system's ability to recognize and eliminate tumor cells. Hence, SIRP gamma recombinant protein research is poised to contribute significantly to the field of immunology and translational medicine.
