Analytical Data
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Gene name
KRT40
- Application
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Alternative Names
KA36; CK-40; K40; Cytokeratin-40; Type I hair keratin Ka36
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6A162
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Expression Region
Met1~Leu431
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Molecular Weight
52kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT40, or keratin 40, is a type of intermediate filament protein primarily expressed in the epithelial cells of the human body. Research into KRT40 recombinant protein has gained traction due to its significant role in providing structural integrity and mechanical resilience in various tissues. Understanding the properties and functions of KRT40 is critical in the context of skin biology and related disorders, as alterations in keratin expression can lead to conditions such as skin keratins' syndromes and cancer. Advances in recombinant DNA technology have enabled the production of KRT40 in heterologous systems, facilitating the study of its biochemical characteristics, post-translational modifications, and interactions with other cellular components. This research not only aids in elucidating the molecular mechanisms underlying keratin-related pathologies but also holds potential for developing therapeutic strategies and biomaterials that harness the unique properties of keratins. Furthermore, KRT40 serves as a valuable biomarker for certain diseases, highlighting the importance of recombinant protein studies in clinical diagnostics and therapeutic interventions. Overall, the exploration of KRT40 recombinant protein is a significant frontier in cell biology, with implications for regenerative medicine and the understanding of epithelial tissue dynamics.
